Journal of Environmental Biology

A genome-wide association study identifying key susceptibility loci for psoriasis: A genetic perspective

B.S. Sindhu¹*, G.P. Chandrasekhar Naidu², Kukkapalli Prathap Kumar³, E.V. Ravikanth⁴ and Usha Adiga⁵     

¹Department of Dermatology, Apollo Institute of Medical Sciences and Research Chittoor, Murukambattu-517 127, India

²Consultant Cardiologist, Sahasra heart and skin care hospital, Chittoor -517 001, India

³Department of otorhinolaryngology, Apollo Institute of Medical Sciences and Research Chittoor, Murukambattu-517 127, India

⁴Department of Dermatology, Apollo Institute of Medical Sciences and Research Chittoor, Murukambattu-517 127, India

⁵Department of Biochemistry, Apollo Institute of Medical Sciences and Research Chittoor, Murukambattu-517 127, India

Received: 29 November 2025                   Revised: 04 May 2026                   Accepted: 12 May 2026

*Corresponding Author Email: sindhu_bs@aimsrchittoor.edu.in                  *ORCiD: https://orcid.org/0009 0004 4146 559X

Abstract

Aim: To identify and functionally characterise key genetic susceptibility loci for psoriasis using GWAS data integrated with pathway, network, and regulatory analyses.

Methodology: GWAS datasets were systematically analysed to identify genes and genetic variants associated with psoriasis. Functional enrichment analyses were performed to delineate key biological pathways, regulatory elements, and functional annotations. Furthermore, transcription factor and microRNA interactions with psoriasis-related genes were evaluated to provide mechanistic insights.

Results: Multiple genetic loci were identified, reaffirming the contribution of immune dysregulation and impaired skin barrier function in psoriasis. Functional enrichment highlighted significant pathways including cytokine signalling, NF-κB activation, and keratinocyte proliferation. Several transcription factors and miRNAs regulating psoriasis-associated genes were also identified, offering additional layers of gene expression control.

Interpretation: Integration of GWAS findings with pathway and regulatory network analyses enhances the understanding of psoriasis genetics. Novel susceptibility genes, transcriptional regulators, and potential biomarkers have been identified, which may serve as therapeutic targets. Future research should focus on experimental validation and clinical translation to advance precision medicine approaches in psoriasis management.

Key words: Genetic susceptibility, GWAS Psoriasis, Immune-related loci, Inflammatory skin disease, Psoriasis genetics

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