Journal of Environmental Biology

Segregation distortion at a microsatellite marker in the olive
flounder, Paralichtys olivaceus

Jung Ha Kang^*1, Jong Hyun Kim², Hyun Chul Kim², Jae Koo Noh², Jeong Ho Lee² and Kyung Kil Kim²

¹Biotechnology Research Institute, National Fisheries Research and Development Institute, 619-902, Republic of Korea
²Genetics and Breeding Research Center, National Fisheries Research and Development Institute, 656-842, Republic of Korea

(Received: June 29, 2007; Revised received: February 18, 2008; Accepted: February 25, 2008)

Abstract: In the course of quantitative trait loci (QTL) analysis of the back cross (BC1) families of olive flounder (Paralichtys olivaceus), we observed significant segregation distortion at a microsatellite marker, Poli9-58TUF in two crosses of informative progenies. The family 1 of the random BC1 progenies derived from a cross between a F1 male genotype (A/B) and  a F1’s female parent genotype (A/C) and the family 2 (A/C x A/C) displayed a strong bias in the locus from the Mendelian inheritance by the elimination of homozygous A/A genotype. The deleterious roles of the AA genotypes are suggested during the metamorphosis and it implies that the parents of these families carried a recessive gene or genes hampering development at an early stage because the offspring of the double heterozygote parents show the reduction in frequency or elimination of one homozygous class, which is an evidence for linkage between the genetic marker and gene(s) with recessive deleterious alleles. This data support a hypothesis that the region contains a recessive lethal gene or genes.

Key words: Segregation distortion, Microsatellites, Paralichtys olivaceus, Lethal gene

PDF of full length paper is available with author (jhkang@nfrdi.re.kr)

Copyright © 2008 Triveni Enterprises. All rights reserved. No part of the Journal can be reproduced in any form without prior permission. Responsibility regarding the authenticity of the data, and the acceptability of the conclusions enforced or derived, rest completely with the author(s).