nstantaneous and historical temperature effects on a-pinene
activities of Heliotropiumindicum isolate against
toxicity evaluation in mice
of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh ? 786004, India.
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh
? 786004, India. ???
Regional Institute of Pharmaceutical
Science and Technology, Agartala ? 799005, India.
Department of Pharmaceutical
Sciences, Dibrugarh University, Dibrugarh
? 786004, India.
19? July 2011
A new compound E was isolated from the methanolic extract of the leaves of Heliotropiumindicum by chromatographic fractionation. In
the present study, the effect of the compound E on reproduction of Helopeltistheivorahas
been evaluated. The acute toxicity study (LD50) and sub-acute
toxicity studies (haematological, biochemical and histopathological parameters) in albino Swiss mice were
carried out to evaluate the safety aspect of the compound E. The compound
showed significant inhibitory effect on the reproductive life of H. theivora. The oviposition
period, fecundity and hatching percentage of H. theivora
were found to be 15.67days, 39.33 and 28.00% respectively after treatment
with 2% compound E, whereas the control value were found to be 20.33 days,
77.67 and 77.33% respectively. The LD50 of the compound was found
to be 780 mg kg-1 in Swiss albino female mice. The compound did
not show any toxicity in mice at sub-lethal dose treatment (78 mg kg-1
b. wt., once daily) for 21 days as evident from different haematological,
biochemical and histopathological parameters in
compound E treated group when compared with control.? ??????
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