Journal of Environmental Biology

Investigating the potential of Bismuth vanadate to combat multidrug-resistant Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus

V. Aswathy¹, S. Sajith¹, R. Shakila¹, S. Vijayanand², B. Vidhya³ and S. Murugan¹*     

¹Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore- 641 114, India

²Department of Lifesciences, Kristu Jayanti College, Bengaluru- 560 077, India

³Department of Applied Physics, Karunya Institute of Technology and Sciences, Coimbatore- 641114, India

Received: 16 April 2024                   Revised: 03 December 2024                   Accepted: 06 January 2025

*Corresponding Author Email : micromurugans@gmail.com                  *ORCiD: https://orcid.org/0000-0002-2432-1883

Abstract

Aim: This study investigated the efficiency of BiVO₄ nanoparticles (BiVO₄ NPs) against drug-resistant bacteria, Acinetobacter baumannii and Methicillin-resistant Staphylococcus aureus (MRSA).

Methodology: The study employed a multifaceted approach, evaluating the ablity of BiVO₄ NPs to inhibit bacterial growth, reduce viable cell counts over time, and hinder biofilm formation. Furthermore, the investigation explored the NPs impact on virulence factors using protease and hemolysin inhibition assays.

Results: The findings showed the potent efficacy of BiVO₄ NPs against A. baumannii and MRSA. Notable results included the formation of clear inhibition zones up to 19 and 15 mm, indicating the antimicrobial activity against both pathogens. BiVO₄ NPs also effectively inhibited biofilm formation, reduced bacterial adherence, and inhibited virulence factors, underscoring their potential as effective agents against drug-resistant bacteria and suggesting promising applications in medical  implants  and  anti-microbial research.

Interpretation: Overall, this study provides compelling evidence supporting the potential use of BiVO₄ Nps as an antimicrobial agent and a promising candidate for addressing various human health concerns.

Key words: Antimicrobial, Antibiofilm, Anti-adhesive, Bismuth vanadate, Nanoparticles

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