Journal of Environmental Biology

Exploring the correlation between environmental pesticide exposure and antioxidant level in recently diagnosed cancer patients

A. Ojha¹*, P. Sahani², S. Shekhar³ and S.K. Mishra⁴      

¹Faculty of Allied Health Sciences, Mahayogi Gorakhnath University Gorakhpur, Gorakhpur-273 007, India

²Deapartment of Biotechnology, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur-273 009, India

³Department of Radiotherapy, All India Institute of Medical Sciences, Gorakhpur-273 008, India

⁴Deapartment of Biotechnology, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur-273 009, India

Received: 17 January 2024                   Revised: 06 February 2024                   Accepted: 20 February 2024

*Corresponding Author Email : anupama.ojha0@gmail.com                  *ORCiD: https://orcid.org/0000-0003-1652-1073

Abstract

Aim: Within biological systems thiol and ascorbic acid are important antioxidant that play roles in the antioxidant defense systems. In this study, we investigated the correlation between environmental pesticide exposure and antioxidant level in recently diagnosed cancer patients.  

Methodology: Blood samples were collected from 87 participants (48 male and 39 female) including control, gallbladder, blood, and oral cancer patients. Serum total thiol content and antioxidant ascorbic acid levels were measured by biochemical method. We also examined whether there is any correlation between the plasma thiol content and ascorbic acid content in cancer prevention.

Results: Analysis indicated that most of the cancer patients belonged to middle age and were mostly non-vegetarian. In the present study, it was found that the total thiol content of cancer pateints was high, while the ascorbic acid content was low in cancer patients as compared to control indicating the role of oxidative stress in cancer development.

Interpretation: The present study suggests that pesticide exposure may increase the total thiol content and negatively impact ascorbic acid content in cancer patients.

Key words: Antioxidant, Blood cancer, Epidemiology, Gallbladder cancer, Oral cancer, Pesticide

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