Metabolomic
screening for therapeutic potential in Mimela sp., an edible insect of
the Arunachal Pradesh region
S. Tukshipa, N. Muni, Prveen and J.
Chakravorty*
Department of Zoology, Rajiv Gandhi
University, Itanagar-791 112, India
*Corresponding
Author Email :
jharna.chakraborty@rgu.ac.in *ORCiD:
https://orcid.org/0000-0003-3705-8970
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Abstract
Aim:
Mimela sp. a small coleopteran beetle is rich in proteins, essential
amino acids, fatty acids, some vitamins and minerals. It contains nutritional
and therapeutic values. Therefore, this study was conducted to identify the
bioactive compounds of aqueous and ethanol extracts of Mimela sp. to
understand its pharmacological/therapeutic importance.
Methodology: The biologically active metabolites were analysed
using Agilent Quadrupole time of flight mass analyser (Q-TOF-MS).
Chromatographic separations were performed using 5 ul of aqueous and
ethanolic sample injected onto an Agilent ultra high performance liquid
chromatography system. Elution was carried out using solvent A (0.1% Formic
acid in water) and solvent B (90% Acetonitrile +10% H2O+ 0.1%
Formic acid) at a flow rate of 300 ul min-1 for 30 min.
Results:
Analysis of both aqueous and ethanol extracts of Mimela sp. showed the
presence of important chemical compounds like alpha amino acids (L-Ornithine,
(R)-(+)-2-Pyrrolidone-5-Carboxylic acid), monoesters (Ethyl hydrogen sulphate,
Carboxylic acid (Benzoic acid), monoterpenoids (Linaylphenylacetate), Cyclic
polyols (D-Pinitol), phenols (Vanillic acid, Phyllohydroquinone) and
polyphenols (Gentisic acid), which have immunological, antibacterial,
antioxidant, anti-inflammatory, anticancer and antiviral properties.
Interpretation: Mimela sp.
contain appreciable number. of bioactive compounds which can be further
isolated and developed as drugs for modern medicines.
Key words: Bio-active, Efficacy, Mimela sp., Secondary
metabolite, Therapeutic
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