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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Jul 2020, 41 (4)                                     Back

nstantaneous and historical temperature effects on a-pinene

Endocrine disruption and infertility: Circulatory hormone and bisphenol A concentrations in infertile Saudi women 


M.A. Beg1,2,*, E. Ahmad1, S.F. Al Basri3, A. Abdelsalam4,5, O.S. Bajouh3, M.S. Jamal1,2, A.M. Abuzenadah1 and I.A. Sheikh1,2 

1King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

3Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah, 22252, Saudi Arabia

4Department of Urology, Faculty of Medicine King Abdulaziz University, Jeddah, 22252, Saudi Arabia

5Theodor Bilharz Research Institute, Giza, 12411, Egypt

*Corresponding Author Email :

Paper received: 21.11.2019??????? ?????????????????????????????????????? Revised received: 20.02.2020????????????? ??????????????????????????????????????????? Accepted: 18.03.2020



Aim: Human infertility is a public problem and a cause of social and psychological complications affecting more than 50 million couples globally. Bisphenol A (BPA) is a ubiquitous environmental endocrine disrupting chemical and has been associated with infertility problems in women.The aim of the present study was to analyze concentrations of bisphenol A and circulating hormones in infertile Saudi women for evaluating the association of BPA with infertility.

Methodology: The present study was done on 43 infertile women for evaluating possible association of systemic BPA concentrations with infertility in Saudi Arabia. The clinical indications were irregular menses, hyper-androgenism, multiple small ovarian cysts, polycystic ovarian syndrome and unexplained infertility. Blood samples from infertile women and a control group of 18 healthy fertile women were analyzed and compared for concentrations of BPA and circulatory hormones.            

Results: The results showed that BPA concentrations were not significantly different between infertile women and controls. BPA concentrations were also not correlated with systemic hormone concentrations in infertile women.      

Interpretation: Serum BPA levels had no association with hormone imbalance in this cohort of infertile Saudi women. However, considering the previous studies that have shown a relationship of BPA with female infertility, an argument can be made that there might be lower exposure of Saudi population to BPA in comparison to BPA analogues such as BPS (according to recent reports). Therefore, it is suggested to conduct more infertility studies that include detection of BPA and its analogues in infertile Saudi women.  

Key words: Bisphenol A, Endocrine disruption, Hormones, Infertility, Saudi Arabia




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