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Abstract - Issue Sep 2018, 39 (5) Back
nstantaneous and historical temperature effects on a-pinene
antiobesity effects of bitter melon water extract and platycodin-D in
genetically obese mice
Sohn1, J.W. Kim2, G.W. Jung2, D.C. Park2,
S.B. Moon2, H.R. Cho2, S.K. Ku3 and J.S.
Bioindustry, College of Medical and Life Sciences, Silla University,
Sasang-gu, Busan, 46958, Republic of Korea
2Glucan corp. #305
Marine Bio-Industry Development Center, Hoenggye-ri 27, Gijan-gun, Busan,
46048, Republic of Korea
Anatomy and Histology, College of Oriental Medicine, Daegu Haany University,
290 Yugok-dong, Gyeongsan-si,
38610, Republic of Korea
Author E-mail: email@example.com
Paper received : 14.12.2016
Revised received : 20.02.2017
Re-revised received :
Accepted : 27.12.2017
charantia water extract and platycodin-D are potent hypoglycemic and
hypolipemic agents. In the present study, anti-obesity effects of these
agents were investigated in various proportions.
Methodology: Test agents were
administered orally (200 mg kg-1 b.wt.) once a day for 28 days to db/m and
db/db mice. There were 15 groups (n = 7 per group): db/m, vehicle control, M.
charantia alone platycodin-D alone, and the various M. charantia :
platycodin-D ratio db/db groups. Animals were assigned to groups according to
body weight and blood glucose level one day before initiation of dosing.
After 28 days of dosing, changes in body weight, blood glucose, epididymal
fat weight, serum leptin, adipose adiponectin and liver triglycerides were
Results: Prior to the
initiation of dosing, db/db mice showed marked obesity compared to
db/m mice (normal littermates), together with severe hyperglycemia.
Epididymal fat weight, serum leptin and liver triglycerides were
significantly increased in obese versus intact controls (p<0.01), with
significant decrease in serum adiponectin and adipose adiponectin content
also seen in the latter group (p<0.01). However, these obesity-related
changes were significantly decreased by treatment with M. charantia
water extract alone or platycodin-D alone, as well as in combination at all
of the tested ratios and more favorable effects were detected in some of the
mixed formula groups compared to those of M. charantia water extract
alone and platycodin-D alone. Among the 11 mixed formulas, M. charantia water
extract: platycodin-D at a ratio of 1:4 showed the most dramatic
Interpretation: Based on the
results of this study, it can be concluded that appropriate mixtures of M.
charantia water extract and platycodin-D exert substantial, synergic
antiobesity effects in obese diabetic mice.
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