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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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        Abstract - Issue Sep 2018, 39 (5)                                                                                                             Back

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Protective effect of folic acid against arsenic induced weight loss during gestation, lactation and postnatal growth in mice


Sh. Mirfakhraie1, Z.J. Masoumeh2*, K. Mojtaba3 and B. Mohammad3

1Department of Entomology, Urmia University, Urmia, West Azarbayjan, 57561 51818, Iran

2Department of Anatomy, Urmia University of Medical Sciences, Urmia, West Azarbayjan, 57561 15111, Iran

3Department of Pathology, Urmia University of Medical Sciences, Urmia, West Azarbayjan, 57561 15111, Iran

*Corresponding Author E-mail:




Key words

Arsenic toxicity

Blood-brain barrier

Folic acid


Postnatal growth 



Publication Data

Paper received : 06.06.2017

Revised received : 01.11.2017

Re-revised received : 13.02.2018

Accepted : 29.03.2018



Aim: The present study aimed to determine weight loss in sodium arsenate exposed pups during gestation, lactation and postnatal growth. Additionally, the protective role of folic acid was also assessed against impaired growth caused by arsenic during three developmental stages.


Methodology: Twenty pregnant albino mice were divided into four groups and received the following treatment in their drinking water from gestational day one (G1): control group, 1 mg l-1 As 1 mg l-1 As + 25 mg kg-1 FA (As + FA) by ip once a week during gestation and lactation and 25 mg kg-1 folic acid (FA) groups. After weaning, the litters were directly exposed to arsenic and folic acid with the same dosage.


Results: Exposure to arsenic exhibited a significant (P<0.01) growth impairment in the weight of offspring during lactation (1st3rd week) and 2256 ds postnatal (PN) in the As-treated group. The administration of FA through gestation and lactation by dams after 2 months could significantly (P<0.01) prevent As-induced weight loss in the developmental stages. Treatment with FA resulted in significantly decrease (P<0.05) of AS level in liver and brain.


Interpretation: These observations indicate that vitamin administration could prevent growth impairments of arsenic exposure.



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