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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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        Abstract - Issue May 2018, 39 (3)                                                                                                             Back



nstantaneous and historical temperature effects on a-pinene

Effect of hexane extract of Syzygium aromaticum on

haematological profile of rats

 

S. Arora1, M. Pal2, M. Bordoloi3 and S. P. Nandi1*

1Amity Institute of Biotechnology, Amity University, Noida-201 313, India

2Division of Forensic Science, School of Basic & Applied Sciences, Galgotias University, Greater Noida-201 306, India

3Natural Product Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat-785 006, India

*Corresponding Author E-mail: spaul@amity.edu

 

 

 

Key words

Haematology

Platelet indices

Rat

RBC indices

Syzygium aromaticum

 

 

 

Publication Data

Paper received : 17.06.2017

Revised received : 23.08.2017

Re-revised received : 08.09.2017

Accepted : 25.09.2017  

 

Abstract

Aim: To analyse the effect of hexane extract of Syzygium aromaticum on haematological profile of rats. 

 

Methodology: Previously, hexane extract of S. aromaticum buds at a high dose of 5000 mg kg-1 was given to one rat and the corresponding control received saline water as vehicle. It was repeated and no mortality was observed. Based on the result, 2000 mg kg-1 was selected for the main study. The rats were prorated into two groups (control and treated). Each group consisted of six rats. After administration of hexane extract, blood was collected from three rats per group at an interval of 1 hr (retero-orbital plexus); 24 hrs and 14 day (cardiac puncture) in ethylenediaminetetraacetic acid coated vials and signs of toxicity and mortality were observed in animals. Haematological parameters were estimated from collected blood samples using automatic haematological analyser (Model Melet Schloesing MS4).

 

Results: The hexane extract of S. aromaticum at a dose of 2000 mg kg-1 b. wt. to male rats did not produce any change in haematological profile for 1 hr exposure. The changes were observed in monocytes and white blood cells after 24 hrs. Significant (P<0.05) changes were observed in red blood cells, haemoglobin, hematocrit, platelets, plateletcrit and platelet distribution widths after 14 days of treatment. The treated rats neither exhibited any signs of toxicity nor death during 14 days of study.      

 

Interpretation: The results revealed that a single dose of 2000 mg kg-1 of Syzygium aromaticum did not induce any impact on haematological profile of rats till 14 day after administration of hexane extract.

 

 

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