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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
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    Abstract - Issue Nov 2017, 38 (6)                                     Back


nstantaneous and historical temperature effects on a-pinene

Characterization of nanorosemary and encapsulated rosemary nanoparticles and their effect on lead induced toxicity in Wistar rats

 

P. Virk1*, M. Elobeid1, M.A.Awad2, A.A. Hendi3, K.M.O. Ortashi4 and M.I. Siddiqui1

1Department of Zoology, King Saud University, Riyadh, 11495, Saudi Arabia

2King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, 11495, Saudi Arabia

3Department of Physics, King Saud University, Riyadh, 11495, Saudi Arabia

4Department of Chemical Engeering,King Saud University, Riyadh, 11495, Saudi Arabia

*Corresponding Author E-mail: virkg@hotmail.com?

 

 

 

Key words

Lead

Nanoencapsulation?

Oxidative stress

Rosemary leaf extract

 

 

Publication Data

Paper received : 19.10.2016???????

Revised received : 11.02.2017????

Re-revised received : 25.04.2017

Accepted : 17.05.2017???????????

 

Abstract

Aim: Lead-induced toxicity is responsible for physiological disarray in humans and animals. The present study was aimed to synthesize'green'nanoparticles of rosemary (Rosmarinus officinalis) leaf extract and investigate the comparative? ameliorative efficacy of rosemary extract and the nanoformulations against the lead toxicity in male Wistar rats.

 

Methodology: Non-capsulated rosemary particles were synthesized with dichloromethane. Encapsulated nanoparticles of rosemary were synthesized with two polymers, starch and a combination of starch with polyvinyl alcohol.The nanoparticles were characterized by transmission electron microscopy and dynamic light scattering.Parallel to this, Wistar rats were exposed to 30 mg Kg-1 lead acetate, four experimental groups were treated with rosemary extract (150 mg Kg-1) as bulk (BR), nanorosemary (RN), encapsulated nanoparticles RN1 and RN2,? respectively, for a period of 21 days. ?????

 

Results: Green synthesis of water soluble nanorosemary (RN) and encapsulated nanoparticles RN1 and RN2, with composite and single polymer, was successfully achieved. The micrographs showed spherical and irregular morphology of RN, while RN1 and RN2 were more spherical.The average size of nanorosemary (RN) was 75.45 nm, while that of encapsulated rosemary nanoparticles (RN1) and RN2 was 2.665 nm and 3.026 nm. Treatment with nanoformulations reduced the level of serum malondialdehyde in the rats. Also, due to their enhanced bioavailability, the nanoparticles efficiently reduced the lead concentrationin tissues compared to the bulk rosemary. ?????????

 

Interpretation: The results demonstrate the enhanced protective efficacy of encapsulated? nanoparticles, in particular RN1. Thus, the formulation could be a potential ecofriendly, safe and novel therapeutic approach against lead toxicity.

 

 

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