studies on antioxidant, anti-melanogenic and anti-wrinkle effects of
medicinal plant Glycyrrhiza uralensis
Ryu1, M.J. Kang1 and M.Y. Lee1,2*
Medical Science, Soonchunhyang University, Asan,Chungnam, 31538, Korea
Medical Biotechnology, Soonchunhyang University,Asan, Chungnam, 31538, Korea
Author E-mail: email@example.com
Paper received : 23.07.2016
Revised received : 19.01.2017
Accepted : 23.03.2017
Aim: The aim of the
present study was to investigate the antioxidant, anti-melanogenic and
anti-wrinkle activity of Glycyrrhiza uralensis (G. uralensis)
for cosmeceutical application.
free radical scavenging activity of 1,3-butylene glycol (1,3-BG) extract of G.
uralensis was analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH),
2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and oxygen
radical absorbance capacity (ORAC) assays. The anti-melanogenesis and
anti-wrinkle effects of G. uralensis extract were also analyzed by
tyrosinase, zymography and collagen assays.
EC50 of 1,3-BG extract of G. uralensis, determined by DPPH and
ABTS assays, was 0.59% and 1.17%, respectively.The ORAC value of the extract
was 41.56 μM trolox equivalent. The G. uralensis extract
inhibited in vitro mushroom tyrosinase activity with an IC50 of
0.6%, and it also reduced melanin contents in mouse melanoma cells. In
addition, the G. uralensis extract notably inhibited matrix
metalloproteinase-2 activity via zymography. Approximately, 60%
collagen production enhancement was observed upon treatment with the extract,
suggesting its anti-wrinkle potential.
1,3-BG extract of G. uralensis may be utilized as a cosmeceutical
ingredient, offering anti-oxidant, brightening and anti-wrinkle effects.
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