effects of curcumin on sodium fluoride induced behavioural and enzymatic
changes in brain and muscles of rat
Nageshwar, K. Sudhakar, N.C.S. Reddy and K.P. Reddy*
Zoology, Osmania University, Hyderabad-500 007, India
Membrane bound enzymes,
received : 24.09.2015
received : 16.07.2016
received : 22.11.2016
Accepted : 30.11.2016
Aim: The study reports
protective role of curcumin, a polyphenolic compound, against sodium fluoride
(NaF) induced oxidative stress, altered cognitive, motor abilities and AChE,
Na+-K+ ATPase activities in rat.
were divided into three groups. The first group received normal tap water
that served as control. The second group was treated with sodium fluoride (20
mg kg-1 b. wt.). The third group was treated with sodium fluoride
(20 mg kg-1 b.wt.)+Curcumin (20 mg kg-1 b.wt.) through
drinking water by gavage for 30 days.
body weight (-22.55%), somatic index (-15%, -26.72%), membrane bound enzymes
Na+-K+ ATPase (-34.72%, -35.97%) and AChE activities
(-44.70%, -38.83%) were significantly (p<0.05) decreased and oxidative
stress marker lipid peroxidation level (67.96%,72.46%)was increased in sodium
fluoride intoxicated group as compared to control group. The motor
coordination (-43.18%, -39.90%), locomotor (-41.45%) and nociceptive pain
(-14.78%, -15.98%) abilities were diminished in sodium fluoride treated group
as compared to control group, whereas body weight, somatic index, membrane
bound enzymes Na+-K+ ATPase, AChE activities, lipid
peroxidation levels and motor coordination, locomotor and nociceptive pain
abilities were significantly (p<0.05) reversed in curcumin treated along
with sodium fluoride group compared to NaF treated group.
results of the present study showed that curcumin ameliorated the oxidative
stress, membrane bound enzyme activities in muscle and brain, as well as
motor, pain and cognitive abilities of rat induced by NaF exposure.