stress and cholinesterase depression among farm
occupationally exposed to pesticides in India
Fareed1,2*, C.N. Kesavachandran1, V. Bihari1,
R. Kamal1 and M. Kuddus3
Division, CSIR - Indian Institute of Toxicology Research, Lucknow-226 001,
Public Health, College of Medicine, Al Imam Muhammad Ibn Saud Islamic
University, Riyadh-13317-4233, Kingdom of Saudi Arabia
Biochemistry, College of Medicine, University of Hail, Hail, 81451, Kingdom
of Saudi Arabia
Author E-mail: firstname.lastname@example.org
received : 16.10.2015
received : 16.05.2016
received : 25.07.2016
Accepted : 20.09.2016
Aim: This study aims to
investigate the oxidative stress and cholinesterase levels among agricultural
workers occupationally exposed to various agricultural pesticides.
cross sectional study was performed among fifty two male pesticide sprayers
of Lucknow district in India, compared with thirty control subjects.
Pesticide sprayers were selected on the basis of clinical examination for
acute and chronic health symptoms associated with pesticide exposure.
examination of pesticide sprayers showed significant health problems
(p<0.05) for different organ systems. Activities of acetylcholinesterase
and butyrylcholinesterase were significantly depressed (p<0.05) among
pesticide sprayers as compared to controls showing the exposure to pesticides
among them. Activity of blood CAT was higher but not statistically
significant; activity of blood GPx was significantly higher (p<0.05);
blood GSH was significantly decreased (p<0.05); blood MDA level was more
in pesticide sprayers as compared to control subjects, but not statistically
significant. These results show the sub-clinical state of oxidative stress
among pesticide sprayers.
present study showed that occupational exposure to pesticides leads to
cholinesterase depression and alterations in anti-oxidant enzymes, eventually
leading to oxidative stress condition.
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