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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Sep 2016, 37 (5)                                     Back


nstantaneous and historical temperature effects on a-pinene

In vitro polysaccharide extraction from Cipangopaludina cathayensis

and its pharmacological potential

 

Chenwei Wang, Jiantao Liu*, Yichi Huang and Xiaohui Zhang

 Jiangxi Key Laboratory of Bioprocess, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi-330 013, China

*Corresponding Author E-mail: zumingli2@gmail.com

 

 Publication Data

Paper received:

21 February 2016

 

Revised received:

27 April 2016

 

Re-revised received:

5 May 2016

 

Accepted:

23 June 2016

 

Abstract

Cipangopaludina cathayensis (mudsnails) is a snail-like animal. This study intends to reveal pharmacological potential of polysaccharide extracted from mudsnails. Crude soluble polysaccharide of mudsnails was extracted using hot water extraction and ethanol precipitation method. The crude polysaccharide was purified successively using Sevag method. Applying Fenton reactions, it was found that antioxidant potential efficiency of polysaccharide extracted from mudsnail was dose-dependent and reached up to 44.29% at 4 mg ml-1 concentration. Most significantly, polysaccharide extracted from mudsnail could efficiently inhibit lung cancer cell line A-549 proliferation in vitro and over 50% cells were killed on applying 300 mg ml-1 of polysaccharide after 24 hrs of post treatment. It implies that mudsnail polysaccharide is a potential anti-tumor agent.   

 

 

 Key words

Antioxidant potential, Anti-tumor properties, Cipangopaludina cathayensis, Polysaccharide

 

 

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