nstantaneous and historical temperature effects on a-pinene
In
vitro polysaccharide extraction from Cipangopaludina cathayensis
and
its pharmacological potential
Chenwei
Wang, Jiantao Liu*, Yichi Huang and Xiaohui Zhang
Jiangxi Key
Laboratory of Bioprocess, Jiangxi Science & Technology Normal University,
Nanchang, Jiangxi-330 013, China
*Corresponding
Author E-mail: zumingli2@gmail.com
Publication
Data
Paper received:
21 February 2016
Revised received:
27 April 2016
Re-revised received:
5 May 2016
Accepted:
23 June 2016
Abstract
Cipangopaludina
cathayensis (mudsnails) is a snail-like animal. This study intends to
reveal pharmacological potential of polysaccharide extracted from mudsnails.
Crude soluble polysaccharide of mudsnails was extracted using hot water
extraction and ethanol precipitation method. The crude polysaccharide was
purified successively using Sevag method. Applying Fenton reactions, it was
found that antioxidant potential efficiency of polysaccharide extracted from
mudsnail was dose-dependent and reached up to 44.29% at 4 mg ml-1
concentration. Most significantly, polysaccharide extracted from mudsnail
could efficiently inhibit lung cancer cell line A-549 proliferation in vitro
and over 50% cells were killed on applying 300 mg ml-1 of
polysaccharide after 24 hrs of post treatment. It implies that mudsnail
polysaccharide is a potential anti-tumor agent.
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