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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
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    Abstract - Issue Mar 2016, 37 (2)                                     Back


nstantaneous and historical temperature effects on a-pinene

Lack of genotoxic potential of pesticides, spinosad, imidacloprid and neem oil in mice (Mus musculus) 

 

 

 

Ankita Saxena1, 3* and V.P. Kesari2

1Institute for Industrial Research and Toxicology, F-209,UPSIDC, M.G.Road, Ghaziabad-201 302, India

2Genotoxicity Lab., Department of Zoology, Patna University, Patna-800 005, India

3Department of Pharmacology and Toxicology, Lab. Life Science Intelligentsia, Chakwara, Hajipur-844 010, India

*Corresponding Author E-mail: ankitarajendraraizada@gmail.com

 

 

Publication Data

Paper received:

30 June 2015

 

Revised received:

11 September 2015

 

Accepted:

06 October 2015

 

Abstract

Pesticides, spinosad, imidacloprid and neem oil are widely used both in residential and agricultural environments because of its broad spectrum insecticidal activity and effectiveness. The present study was undertaken to estimate genotoxicity of formulations of some pesticides in mice. Three pesticides of diverse group studied were spinosad (45% w/v), imidacloprid (17.8%, w/v) and neem oil. Animals were exposed 37,4.5 and 50 mg kg-1 b.wt. for spinosad, imidacloprid and neem oil, respectively, through oral gavage for 5 consecutive days. A vehicle control group and one positive control (cyclophosphamide; 20 mg kg-1b. wt.) were also selected. The results showed that cyclophosphamide produced 1.12% micronuclei in mice, as against 0.18 in vehicle control, 0.30 in spinosad, 0.28 in imidacloprid and 0.22% in neem oil, respectively. The gross percentage of chromosomal aberration in mice were 28.5% in cyclophosphamide against 6.5% in vehicle control, 8.0% in spinosad, 9.5% in imidacloprid and 7.0% in neem oil, respectively. The overall findings of the present study revealed that all the three pesticide formulations, imidacloprid, spinosad and neem oil at tested dose did not show any genotoxic effect in mice.? ??????  

 

 

 Key words

Chromosomal aberration, Genotoxicity, Imidacloprid, Mice, Neemoil, Spinosad

 

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