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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Sep 2015, 36 (5)                                     Back

nstantaneous and historical temperature effects on a-pinene

Evaluation of antisecretory, gastroprotective and in-vitro antacid capacity of Fumaria indica in rats


Phool Chandra1*, Kamal Kishore2 and Ashoke Kumar Ghosh1

1School of Pharmaceutical Sciences, IFTM University, Moradabad-244 102, India

2Department of Pharmacy, MJP Rohilkhand University, Bareilly-243 006, India

*Corresponding Author E-mail:




Publication Data

Paper received:

26 April 2014


Revised received:

14 October 2014


Re-revised received:

30 November 2014



08 December 2014



Fumaria indica is used for its anthelmintic, antidyspeptic, cholagogue, diaphoretic, diuretic, laxative, stomachic, tonic properties and claimed to possess various properties for the ailments of blood, skin, gastrointestinal systems and central nervous system. The present study was undertaken to evaluate antisecretory, gastroprotective and in-vitro antacid capacity of ethanol extract from F. indica in rats. Evaluation of F. indica extract as antisecretory was carried out by pyloric ligation induced ulcer model. The gastroprotective effect was carried out by absolute ethanol induced ulcer model. Integrity of gastric mucosa was evaluated by estimation of GSH and gastric mucus level. The in-vitro antacid capacity was evaluated by titration method. Ethanol extract of F. indica at 200 mg kg-1, orally showed inhibition of secretion in pyloric ligation model. GSH level (1.67 ?g mg-1 protein), gastric wall mucus (240.76 ?g g-1 wet glandular tissue) and percentage protection (77.59%) of ulcer were significantly (P<0.05) increased in absolute ethanol induced ulcer model. The in-vitro antacid capacity of ethanol extract of F. indica was compared with the standard. Conclusively, it appears that F. indica possess antisecretory (inhibition of acid secretion), gastroprotective (potentiation of defensive factors) and in-vitro antacid activity.    



 Key words

Antacid, Antisecretory, Fumaria indica, Gastroprotective



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