Evaluation
of antisecretory, gastroprotective and in-vitro antacid capacity of Fumaria
indica in rats
Phool Chandra1*,
Kamal Kishore2 and Ashoke Kumar Ghosh1
1School of
Pharmaceutical Sciences, IFTM University, Moradabad-244 102, India
2Department of
Pharmacy, MJP Rohilkhand University, Bareilly-243 006, India
*Corresponding
Author E-mail: chandraphool@yahoo.co.in
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Publication
Data
Paper received:
26 April 2014
Revised received:
14 October 2014
Re-revised received:
30 November 2014
Accepted:
08 December 2014
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Abstract
Fumaria
indica is used for its anthelmintic, antidyspeptic, cholagogue,
diaphoretic, diuretic, laxative, stomachic, tonic properties and claimed to
possess various properties for the ailments of blood, skin, gastrointestinal
systems and central nervous system. The present study was undertaken to
evaluate antisecretory, gastroprotective and in-vitro antacid capacity
of ethanol extract from F. indica in rats. Evaluation of F. indica
extract as antisecretory was carried out by pyloric ligation induced ulcer model.
The gastroprotective effect was carried out by absolute ethanol induced ulcer
model. Integrity of gastric mucosa was evaluated by estimation of GSH and
gastric mucus level. The in-vitro antacid capacity was evaluated by titration
method. Ethanol extract of F. indica at 200 mg kg-1, orally
showed inhibition of secretion in pyloric ligation model. GSH level (1.67 ?g
mg-1 protein), gastric wall mucus (240.76 ?g g-1 wet
glandular tissue) and percentage protection (77.59%) of ulcer were
significantly (P<0.05) increased in absolute ethanol induced ulcer model.
The in-vitro antacid capacity of ethanol extract of F. indica was
compared with the standard. Conclusively, it appears that F. indica
possess antisecretory (inhibition of acid secretion), gastroprotective
(potentiation of defensive factors) and in-vitro antacid activity.
Key
words
Antacid,
Antisecretory, Fumaria indica, Gastroprotective
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