Journal of Environmental Biology

Synthetic and biological studies on thioxoquinazolinone

substituted isoxazoles

K. Lakshmi¹*, N. Rama Rao¹ and M.V. Basaveswara Rao²

¹Chalapathi Institute of Pharmaceutical Sciences, Chalapathinagar, Guntur-522 034, India

²Krishna University, Dr. MRAR PG Centre, Nuzvid-521 201, India

*Corresponding Author?s E-mail: lakshminageswar@gmail.com

Publication Data

Paper received:

21 February 2014

Revised received:

23 July 2014

Accepted:

21 August 2014

Abstract

Eighteen novel 5-phenyl-3-(substitutedthioxoquinazolinonyl) isoxazoles (5a-r) were synthesized by cycloaddition of various chalcones with hydroxylaminehydrochloride (NH₂OH.HCl). All the newly synthesized compounds were confirmed by their spectral and analytical data. They were evaluated for antimicrobial, antihelminthic, analgesic and anti-inflammatory activities with an objective to evaluate the effect of thioxoquinazolinone substituted isoxazoles. Compounds 5a, 5f, 5g, 5k and 5l showed significant antimicrobial, anthelmintic, analgesic and anti-inflammatory activities. Further, isoxazoles having bromo substituted thioxoquinazolinones exhibited excellent activities than iodo substituted thioxoquinazolinones. ??  

 Key words

Analgesic, Antimicrobial, Egg white, Isoxazoles, 2-thioxo-4 (3H) quinazolinones

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