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Abstract - Issue Mar 2015, 36 (2) Back
nstantaneous and historical temperature effects on a-pinene
study on the interaction of flavonoids with fat mass
obesity associated protein
Alharbi, Rabbani Syed* and Imran Ali Khan
Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud
P.O. Box 10219,
Riyadh-11433, Saudi Arabia
Authors Email : email@example.com
03 October 2013
24 April 2014
20 June 2014
is a complex metabolic disorder linked to an increased risk of the most
common and severe human diseases. Several flavonoids are known to have
lipolytic activity influencing lipolysis and adipogenesis in adipose cells.
In the current study, the inhibitory effect of various flavonoid compounds on
fat mass and obesity associated protein (FTO) was assessed. The protein
structure of FTO (3LFM) was downloaded from Protein Data Bank. The inhibitory
effect of flavonoids was compared with a known clinical anti obesity drug.
Autodock tools were used for docking flavonoids and antiobesity drug orlistat
with FTO. It was examined that flavonoid quercetin proved maximum affinity
(most negative ∆G), while daidzein showed no affinity towards FTO. The
empathy of other flavonoids was in the order of Exemestane > Kaempherol
> Letrozole > Rutin. It was concluded that flavonoids (particularly
quercetin) may act as an effective drug against fat mass and obesity
associated protein. Anti obesity drug, orlistat was also incorporated in the
study to prove that quercetin could be a potent inhibitor for FTO.
Obesity, Obesity associated protein, Orlistat, Quercetin
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