Journal of Environmental Biology

Computational study on the interaction of flavonoids with fat mass

and obesity associated protein

Khalid Khalaf Alharbi, Rabbani Syed* and Imran Ali Khan

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University,

P.O. Box 10219, Riyadh-11433, Saudi Arabia

*Corresponding Authors Email : rabbanisyd@gmail.com

Publication Data

Paper received:

03 October 2013

Revised received:

24 April 2014

Accepted:

20 June 2014

Abstract

Obesity is a complex metabolic disorder linked to an increased risk of the most common and severe human diseases. Several flavonoids are known to have lipolytic activity influencing lipolysis and adipogenesis in adipose cells. In the current study, the inhibitory effect of various flavonoid compounds on fat mass and obesity associated protein (FTO) was assessed. The protein structure of FTO (3LFM) was downloaded from Protein Data Bank. The inhibitory effect of flavonoids was compared with a known clinical anti obesity drug. Autodock tools were used for docking flavonoids and antiobesity drug orlistat with FTO. It was examined?? that flavonoid quercetin proved maximum affinity (most negative ∆G), while daidzein showed no affinity towards FTO. The empathy of other flavonoids was in the order of Exemestane > Kaempherol > Letrozole > Rutin.? It was concluded that flavonoids (particularly quercetin) may act as an effective drug against fat mass and obesity associated protein. Anti obesity drug, orlistat was also incorporated in the study to prove that quercetin could be a potent inhibitor for FTO. ?? 

 Key words

Flavonoids, Obesity, Obesity associated protein, Orlistat, Quercetin 

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