Neurotoxic
impact of organophosphate pesticide phosphomedon
on
the albino rat
Ranjit Hazarika
Zoology
Department, M.C. College, Barpeta-781 301, India
*Corresponding
Author E-mail: rranjit96 @rediffmail.com
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Publication
Data
Paper received:
31 March 2012
Revised received:
16 July 2013
Accepted:
19 August 2013
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Abstract
Organophosphate
pesticide phosphomedon was exposed to albino rat at a concentration of 35 ppm
in the time interval of 30, 45 and 60days. During the exposure period
neurobehavioral symptoms such as reduce food intake, weight loss, increase
water intake, low defecation frequency, increase locomotion frequency at high
dose were observed. Locomotion frequency were less initially but higher in
increasing dose concentration. The result was also different in both the
sexes. A decrease social interaction and increase force swimming with
increasing dose concentration,which was not significant as comparison to
control. Asignificant histopathological changes observed in three dose
concentrations. In 30 days phosphomedon exposure the nuclear shape changes to
oval, pear shaped along with fibrosis, lipidosis, 45 days exposure showed the
increase number of nucleus, Chromatolysis, inflammatory nucleus, pyknosis. In
60 days test group histopathological picture showed the swelling of cell
body, lipidosis, demylination, necrosis in brain cells. Over all result
indicated that due to impact of O. P pesticide phosphomedon a severe
histopathological changes occurs which was distinctly observed in
neurobehavioural changes.
Key
words
Brain
tissue, Histopathological, Necrosis-demyelization, Neurobehavioural changes,
Phophomedon
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