Journal of Environmental Biology

Studies on liver damage induced by nanosized-titanium
dioxide in mouse

Yu-Mi Jeon¹, Wan-Jong Kim²?and Mi-Young Lee¹*

¹Department of Medical Biotechnology, Soonchunhyang University, Asan, Chungnam 336-600, Republic of Korea

²Department of Life Science and Biotechnology, Soonchunhyang University, Asan, Chungnam 336-600, Republic of Korea

*Corresponding Author email : miyoung@sch.ac.kr

Publication Data

Paper received:

19 October 2011

Revised received:

25 April 2012

Accepted:

26 May 2012

Abstract

The aim of the study was to examine the liver tissue damage induced by nanosized-TiO₂?in mouse. The biochemical parameters of liver, namely glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and alkaline phosphatase were enhanced approximately 18%, 35% and 69% by exposure to nanosized-TiO₂, respectively. The nanosized-TiO₂?accumulated in the periphery of sinusoid in liver when the ultrastructure was examined through transmission electron microscopy. Enzymes, such as superoxide dismutase, catalase and aldehyde dehydrogenase were significantly inhibited by 22%, 38% and 15%, respectively, whereas glutathione peroxidase was constant following exposure to nanosized-TiO₂.

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Key words

Nanosized-TiO2, Toxicity, Mouse, Liver

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