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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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        Abstract - Issue Mar 2013, 34 (2)                                                                                                             Back

nstantaneous and historical temperature effects on a-pinene

Studies on liver damage induced by nanosized-titanium
dioxide in mouse


Yu-Mi Jeon1, Wan-Jong Kim2and Mi-Young Lee1*

1Department of Medical Biotechnology, Soonchunhyang University, Asan, Chungnam 336-600, Republic of Korea

2Department of Life Science and Biotechnology, Soonchunhyang University, Asan, Chungnam 336-600, Republic of Korea

*Corresponding Author email :



Publication Data

Paper received:

19 October 2011


Revised received:

25 April 2012



26 May 2012



The aim of the study was to examine the liver tissue damage induced by nanosized-TiO2in mouse. The biochemical parameters of liver, namely glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and alkaline phosphatase were enhanced approximately 18%, 35% and 69% by exposure to nanosized-TiO2, respectively. The nanosized-TiO2accumulated in the periphery of sinusoid in liver when the ultrastructure was examined through transmission electron microscopy. Enzymes, such as superoxide dismutase, catalase and aldehyde dehydrogenase were significantly inhibited by 22%, 38% and 15%, respectively, whereas glutathione peroxidase was constant following exposure to nanosized-TiO2.


Key words

Nanosized-TiO2, Toxicity, Mouse, Liver


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