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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Nov 2012, 33 (6)                                     Back


nstantaneous and historical temperature effects on a-pinene

Single dose toxicity studies of sulfated water soluble b-D-glucan
in Sprague-Dawley rats

 

Author Details

 

Yong Hyun Kim       

Department of Biology, Soonchunhyang University, Asan City 336-745, South Korea

Jong Yoon Paek

Department of Biology, Soonchunhyang University, Asan City 336-745, South Korea

Hyun-Woung Shin

Department of Marine Biotechnology, Soonchunhyang University, Asan City 336-745, South Korea

Man-Deuk Han

(Corresponding author)

Department of Biology, Soonchunhyang University, Asan City 336-745, South Korea

e-mail: mdhan@sch.ac.kr

 

 

Publication Data

Paper received:

17 November 2009

 

Revised received:

05 January 2011

 

Accepted:

25 February 2011

 

Abstract

The fungal b-D-glucan is a biological response modifier (BRM), but a major obstacle to the clinical utilization of these BRMs is their relative insolubility in aqueous media. We made soluble sulfated-b-glucan (SGL) from insoluble b-glucan (IGL) by sulfation method. In single dose toxicity study of SGL for 7 days, no negative effects on body weight or food consumption of rats were evident below a dose rate of 2,000 mg kg-1 SGL. No clinical pathology, functional/behavioral, or gross observations indicating toxicity were detected. In hematology and biochemistry, statistically significant increases of WBC and neutrophils (P<0.01) in male and increase of MCV (P<0.05) in females was observed. However, since the changes were not dose?responsive, the effects were considered to be of no toxicological significance. These results suggest that chemically modified sulfated-b-D-glucan was less toxic than the insoluble b-glucan and not considered acutely toxic following peritoneal exposure to 2,000mg kg-1 day-1 in Sprague-Dawley rats.

 

Key words

Sulfated-b-D-glucan, Ganoderma lucidum, Single dose toxicity

 

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