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Abstract - Issue Nov 2012, 33 (6) Back
nstantaneous and historical temperature effects on a-pinene
Single dose
toxicity studies of sulfated water soluble b-D-glucan
in Sprague-Dawley rats
Author
Details
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Yong
Hyun Kim
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Department
of Biology, Soonchunhyang University, Asan City 336-745, South Korea
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Jong
Yoon Paek
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Department
of Biology, Soonchunhyang University, Asan City 336-745, South Korea
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Hyun-Woung
Shin
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Department
of Marine Biotechnology, Soonchunhyang University, Asan City 336-745, South
Korea
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Man-Deuk
Han
(Corresponding author)
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Department of Biology, Soonchunhyang University, Asan City
336-745, South Korea
e-mail: mdhan@sch.ac.kr
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Publication
Data
Paper received:
17 November 2009
Revised received:
05 January 2011
Accepted:
25
February 2011
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Abstract
The fungal b-D-glucan is a biological response modifier (BRM), but a major
obstacle to the clinical utilization of these BRMs is their relative
insolubility in aqueous media. We made soluble sulfated-b-glucan
(SGL) from insoluble b-glucan (IGL) by sulfation method. In single dose toxicity study
of SGL for 7 days, no negative effects on body weight or food consumption of
rats were evident below a dose rate of 2,000 mg kg-1 SGL. No clinical
pathology, functional/behavioral, or gross observations indicating toxicity
were detected. In hematology and biochemistry, statistically significant
increases of WBC and neutrophils (P<0.01) in male and increase of MCV
(P<0.05) in females was observed. However, since the changes were not
dose?responsive, the effects were considered to be of no toxicological
significance. These results suggest that chemically modified sulfated-b-D-glucan
was less toxic than the insoluble b-glucan and not considered
acutely toxic following peritoneal exposure to 2,000mg kg-1 day-1 in Sprague-Dawley
rats.
Key words
Sulfated-b-D-glucan, Ganoderma lucidum, Single dose toxicity
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