nstantaneous and historical temperature effects on a-pinene
Chemopreventive potential of geraniol in 7,12-dimethylbenz(a)
anthracene (DMBA) induced skin carcinogenesis in Swiss
Department of Biochemistry and Biotechnology, Faculty of
Annamalainagar - 608 002,
of Biochemistry and Biotechnology, Faculty of Science, AnnamalaiUniversity,
Annamalainagar - 608 002, India????
10 January 2011
The present study
investigated the chemopreventive potential of geraniol, an acyclic monoterpene
alcohol, by monitoring the tumor incidence and analyzing the status of phase
II detoxification agents, lipid peroxidation by products
and antioxidants in 7, 2-dimethylbenz(a)anthracene (DMBA)?
induced mouse skin carcinogenesis. Skin tumor was developed by
painting DMBA (25 mg in 0.1
ml acetone mouse-1) in the shaved back of the mice, twice weekly
for 8 weeks. We noticed 100% skin tumor formation in mice treated with DMBA
alone. The status of phase II detoxification agents and antioxidants were
decreased where as lipid peroxidation by products
were increased in tumor bearing mice. Oral administration of geraniol at a dose of 250 mg kg-1 body weight
significantly prevented the tumor formation as well as brought back the
status of phase II detoxification agents, lipid peroxidation
by products and antioxidants to near normal range in DMBA treated mice.
Present results suggest that geraniol might have
inhibited abnormal cell proliferation occurring in skin carcinogenesis by
modulating the activities of phase II detoxification agents and through its
free radical scavenging potential.
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