nstantaneous and historical temperature effects on a-pinene
Inhibition of oral pathogens
and collagenase activity by seaweed extracts
Author Details
Jae-SukChoi
RISCenter,
Industry-Academic Cooperation Foundation, SillaUniversity,
Busan 617-736, Korea
Yu-Mi
Ha
RISCenter, Industry-Academic
Cooperation Foundation, SillaUniversity, Busan
617-736, Korea
Chi-Un
Joo
RISCenter,
Industry-Academic Cooperation Foundation, SillaUniversity,
Busan 617-736, Korea
KwangKeunCho
Department
of Animal Resources Technology, GyeongnamNationalUniversity of Science
and
Technology,
Chinju 660 - 758, Korea
Sung-JoKim
Department
of Periodontology, School
of Dentistry, PusanNationalUniversity,
Yangsan,
Gyeongnam? 626-870, Korea
In
Soon Choi
(Corresponding author)
Department
of Biological Science, SillaUniversity, Busan
617-736, Korea
e-mail:
ischoi@silla.ac.kr
Publication Data
Paper received:
12
June 2010
Revised
received:
03
March 2011
Accepted:
21 April 2011
Abstract
Fifty-seven species of common
seaweed from the Coast of Korea
were screened for antimicrobial (i.e.
inhibition of Prevotellaintermedia and Porphyromonasgingivalis growth) activity. As a source of
bioactive compounds, seaweeds can produce many secondary metabolites with a
variety of activities. Using the agar diffusion method, only 17 species
(29.8%) showed inhibitory activity. Of these, methanol extracts of Enteromorphalinza,Sargassumsagamianum, andUlvapertusashowed
strong inhibitory effects against both P. intermedia
and P. gingivalis. The MIC values of E. linza, S. sagamianum, and
U. pertusaextracts against P. intermediawere 625, 78 and 625 ?g ml-1
and those against P. gingivalis were 312,
156 and 625 ?g ml-1, respectively. When these three species?
extracts were separated into five fractions according to their polarity, the
main active agents were determined to be phenolic
compounds. We then compared the antimicrobial activities of these phenolic compounds against various periodontal pathogens
using a MIC test. Phenolic compound containing
extracts at concentrations of 10 to 100 ?g ml-1 showed a
moderate to significant inhibitory effect on collagenase
1, 2 and 3 activity.
Copyright ? 2012 Triveni Enterprises. All rights reserved. No part
of the Journal can be reproduced in any form without prior
permission. Responsibility regarding the authenticity of the data, and
the acceptability of the conclusions enforced or derived, rest completely
with the author(s).
