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Journal of Environmental BiologypISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP |
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Abstract - Issue Sep 2010, 31 (5) BackProtective effect of kombucha mushroom (KM) tea on phenol-induced cytotoxicity in albino mice 1Department
of Medical Pharmacology, Internal Medical Sciences Division, Faculty
of Medicine, 2Department of Biology,
Faculty of Science and 3Department
of Pathology, Veterinary Control and Research Institute, 42080,
Meram, (Received: Abstract: The present study was carried out to
evaluate the protective role of kombucha mushroom
(KM) tea on cytotoxicity induced by phenol (PHE) in mice.
We used weight gain and micronucleus (MN) frequency as indicators of cytotoxicity, and supported these parameters with
pathological findings. The animals were randomly divided into seven groups:
(Group I) only tap water (Group II) 1000 ?l kg-1 b. wt KM?tea,
(Group III) 35 mg kg-1 body wt. PHE (Group IV) 35 mg kg-1
body wt. PHE + 250 ?l kg-1 b. wt KM?tea (Group V) 35 mg kg-1
b. wt PHE + 500 ?l kg-1 b. wt KM?tea (Group VI) 35 mg kg-1
b. wt PHE + 750 ?l kg-1 b. wt KM?tea, (Group VII) 35 mg kg-1
b. wt PHE + 1000 ?l kg-1 b. wt KM?tea, for 20 consecutive days by
oral gavage. The results indicated that all KM?tea
supplemented mice showed a lower MN frequency than erythrocytes in
only PHE?treated group. There was an observable regression on account of
lesions in tissues of mice supplemented with different doses of KM?tea in
histopathological observations. In conclusion, the KM?tea supplementation decreases
cytotoxicity induced by PHE and its protective role
is dose-dependent. Key
words:
In-vivo micronucleus assay, Kombucha
mushroom tea, Phenol toxicity, Pathology, Weight gain ??????? PDF of full length paper
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