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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Sep 2010, 31 (5)                                     Back


abstract_01

Protective effect of kombucha mushroom (KM) tea on phenol-induced

cytotoxicity in albino mice

 

Kursad yapar*1, Kultigin Cavusoglu2, Ertan Oruc3 and Emine yalcin2

1Department of Medical Pharmacology, Internal Medical Sciences Division, Faculty of Medicine,

Giresun University, 28100, Giresun, Turkey

 

2Department of Biology, Faculty of Science and Art, Giresun University, 28049, Debboy Location, Giresun, Turkey

 

3Department of Pathology, Veterinary Control and Research Institute, 42080, Meram, Konya, Turkey

(Received: January 31, 2009; Revised received: July 22, 2009; Accepted: August 07, 2009)

 

Abstract: The present study was carried out to evaluate the protective role of kombucha mushroom (KM) tea on cytotoxicity induced by phenol (PHE) in mice. We used weight gain and micronucleus (MN) frequency as indicators of cytotoxicity, and supported these parameters with pathological findings. The animals were randomly divided into seven groups: (Group I) only tap water (Group II) 1000 ?l kg-1 b. wt KM?tea, (Group III) 35 mg kg-1 body wt. PHE (Group IV) 35 mg kg-1 body wt. PHE + 250 ?l kg-1 b. wt KM?tea (Group V) 35 mg kg-1 b. wt PHE + 500 ?l kg-1 b. wt KM?tea (Group VI) 35 mg kg-1 b. wt PHE + 750 ?l kg-1 b. wt KM?tea, (Group VII) 35 mg kg-1 b. wt PHE + 1000 ?l kg-1 b. wt KM?tea, for 20 consecutive days by oral gavage. The results indicated that all KM?tea supplemented mice showed a lower MN frequency than erythrocytes in only PHE?treated group. There was an observable regression on account of lesions in tissues of mice supplemented with different doses of KM?tea in histopathological observations. In conclusion, the KM?tea supplementation decreases cytotoxicity induced by PHE and its protective role is dose-dependent.

Key words: In-vivo micronucleus assay, Kombucha mushroom tea, Phenol toxicity, Pathology, Weight gain

??????? PDF of full length paper is available online

 

 

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