Journal of Environmental BiologypISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP |
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Abstract - Issue Nov 2009, 30 (6) BackSynthesis and in vitro evaluation
of 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide for potential
anti-proliferative effects Michio
Fujie1,2, Satoki Nakamura3, Kazuhide
Asai1, 1Departament of Materials Science,
Graduate 2Research
3Department
of Internal Medicine III, 4Department
of Nano Materials, Graduate (Received: Abstract: A novel phospha
sugar analogue, 2,3-dibromo-3-methyl-1-phenylphospholane
1-oxide (DBMPP), was prepared from 1-phenyl-3-methyl-2- phospholene
1-oxide and evaluated by in vitro MTT method for leukemia cells and microscopic
observations for solid tumor cells, e.g., stomach cancer cells.? The evaluation revealed clearly that the
synthesized phospha sugar analogue DBMPP has
competent potentials and excellent anti-cancer activities that killed
selectively and specifically the leukemia cells of cell lines of K562 and U937
but did not give any damages on healthy leukocyte.? Moreover, it was revealed that DBMPP killed
solid cancer cells such as stomach cancer cells and melanoma of cell lines of
MKN45 and G361.? Therefore, DBMPP should
exert anti-proliferative effects for different kinds
of tumor cells based on the in vitro evaluations.? The cell cycle analyses by flow cytometry for K562 and U937 cells clearly demonstrated that
the mechanism of the anti-proliferative effect on the
human tumor cells is apoptosis induced by DBMPP. Key words: Human tumor cell lines, 3-(4,5-Dimethythiazol-2-yl)-2,5-diphenyl-2H-tetrazolium
bromide (MTT), Apoptosis, DBMPP, Phospha sugars, Carcinostatic drug ???????????? PDF of full length
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