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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Sep Supplement 2009, 30 (5)                                     Back


Abstract _25

Responses of parathyroid gland, C cells, and plasma calcium and inorganic phosphate levels in rat to sub-lethal heroin administration

 

S.R. Barai1, S.A. Suryawanshi2 and A.K. Pandey*3

1Department of Zoology, Udai Pratap Autonomous College, Varanasi - 221 002, India

2Swami Ramanand Teerth Marathwada University, Nanded - 431 606, India

3National Bureau of Fish Genetic Resources, Lucknow - 226 002, India

(Received: January 17, 2008; Revised received: May 23, 2008; Accepted: January 27, 2009)

 

Abstract: In order to record the effects of heroin on plasma calcium (Ca) and inorganic phosphate (Pi) levels as well as parathyroid gland and C cells, two sub-lethal doses (0.50 LD50 and 0.75 LD50) of the drug were administered intramuscularly in Rattus norvegicus for 30 days. Plasma Ca level of control rats ranged between 9.53?0.32 - 9.88?0.22 mg 100 ml-1 while plasma Pi concentration fluctuated between 4.55?0.18 - 4.71?0.24 mg 100? ml-1. Sub-lethal heroin administration induced progressive increase in plasma Ca level during the first seven days (p <0.001), thereafter the level declined on day 15 and 30. However, plasma Pi level of the heroin-treated rats registered increase with the peak value (p <0.001) on day 30. The treatment elicited degenerative changes in parathyroid gland as evident by cytoplamic vacuolization, presence of more pycnotic nuclei and occurrence of patchy areas among the chief cells. Degenerative changes were also noticed in cristae of mitochondria, Golgi complex and endoplasmic reticulum. There was decrease in chromatin material in the nucleus and loss of hormone granules in the cytoplasm. Oxyphil cells of the heroin-treated rat depicted dilation of endoplasmic reticulum and damaged cristae. Sub-lethal heroin administration in the rat for 30 days induced dilation in endoplasmic reticulum and loss of secretory granules in C cells.??

Key words: Heroin, Plasma calcium, Plasma inorganic phosphate, Parathyroid gland, Oxyphil cells, C cells, Rattus norvegicus

?????? ?PDF of full length paper is available online

 

 

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