Journal of Environmental BiologypISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP |
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Abstract - Issue Sep Supplement 2009, 30 (5) BackResponses
of parathyroid gland, C cells, and plasma calcium and inorganic phosphate
levels in rat to sub-lethal heroin administration S.R. Barai1,
1Department of Zoology,
2Swami 3National Bureau of Fish Genetic Resources, (Received: Abstract: In order to record the effects of
heroin on plasma calcium (Ca) and inorganic phosphate (Pi) levels as well as
parathyroid gland and C cells, two sub-lethal doses (0.50 LD50 and
0.75 LD50) of the drug were administered intramuscularly in Rattus norvegicus for 30 days.
Plasma Ca level of control rats ranged between 9.53?0.32 - 9.88?0.22 mg 100 ml-1
while plasma Pi concentration fluctuated between 4.55?0.18 - 4.71?0.24 mg 100? ml-1.
Sub-lethal heroin administration induced progressive increase in plasma Ca level
during the first seven days (p <0.001), thereafter the level declined on day
15 and 30. However, plasma Pi level of the heroin-treated rats registered
increase with the peak value (p <0.001) on day 30. The treatment
elicited degenerative changes in parathyroid gland as evident by cytoplamic vacuolization, presence of more pycnotic nuclei and occurrence of patchy areas among the
chief cells. Degenerative changes were also noticed in cristae
of mitochondria, Golgi complex and endoplasmic
reticulum. There was decrease in chromatin material in the nucleus and loss of
hormone granules in the cytoplasm. Oxyphil cells of
the heroin-treated rat depicted dilation of endoplasmic reticulum and damaged cristae. Sub-lethal heroin administration in the rat for 30
days induced dilation in endoplasmic reticulum and loss of secretory
granules in C cells.?? Key
words: Heroin, Plasma calcium,
Plasma inorganic phosphate, Parathyroid gland, Oxyphil
cells, C cells, Rattus norvegicus ?????? ?PDF of full length paper is available online Copyright ? 2009 Triveni Enterprises. All rights reserved. No part of the Journal can be reproduced in any
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