Journal of Environmental Biology
pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
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Abstract - Issue Sep 2009, 30 (5) Back
Study of genetic polymorphism in solvent exposed population and its
correlation to in vitro effect of trichloroethylene on lymphocytes
Kumar1, Shikha Tewari1, Priti Sharma1,
1Petroleum Toxicology Division, 2Cell
Biology Section, Indian Institute of Toxicology Research,
Abstract: Trichloroethylene (TCE) is major
industrial pollutant that contaminate environment. Its exposure may lead to hepato-renal toxicity along with the cancer progression.
Although extensive research is done on its toxicity, still not much is known
about its genotoxic potential on humans in relation
to genetic polymorphism. Cytochrome P450 (CYP P-450)
and glutathione-S-transferases (GSTs)
are important in cellular detoxification of TCE. Variations in gene sequences
result in population specific regional genetic variations (polymorphism).
Genotyping of CYP1A1, GSTM1, GSTT1 and GSTP1 polymorphism was performed in 220
normal and 97 solvent-exposed individuals from northern part of
Key words: Genotoxicity, TCE, Lymphocytes, CYP1A1, GSTP1, Real time PCR
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