Journal of Environmental Biology
pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
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Abstract - Issue Jul 2008, 29 (4) Back
Anti-inflammatory activities of methanol extracts from various seaweed species
Mohammed N.A. Khan1, Jae Suk Choi1, Min Chul Lee2, Eliya Kim3, Taek Jeong Nam1, Hitoshi Fujii2 and Yong Ki Hong*1
1Faculty of Food Science and
Biotechnology, and Institute of Fisheries Sciences, Pukyong
(Received: March 13, 2007; Revised received: November 29, 2007; Accepted: December 05, 2007)
Abstract: Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity. Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml–1 of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively. These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively. IC50 values of U. pinnatifida were 10, 15, and 18 mg ml–1 when inflammation symptoms of edema, erythema, and blood flow, respectively, were measured. The IC50 of U. linza was 20, 26, and 31 mg ml–1 when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence.
Key words: Anti-inflammation, Seaweed, Ulva linza, Undaria pinnatifida
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