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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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        Abstract - Issue Jul 2008, 29 (4)                                                                                                             Back


Antioxidant activity of mojabanchromanol, a novel chromene, isolated
from brown alga Sargassum siliquastrum

Sun Hee Cho1, Ji Young Cho2, Se Eun Kang1, Yong Ki Hong1 and Dong Hyun Ahn*1

1Faculty of Food Science and Biotechnology, Pukyong National University, Busan, 608-737, Korea
2Department of Marine Biotechnology, Soonchunhyang University, Asan, 336-900, Korea

(Received: March 13, 2007; Revised received: December 18, 2007; Accepted: December 19, 2007)

Abstract: Silica gel chromatography, HPLC, EI -Mass, and NMR analyses were performed in order to determine the structure obtained from the separation and refinement of the main components of an ethanol extraction of Sargassum siliquastrum, which indicated its antioxidant activity. An ethanol extraction of Sargassum siliquastrum demonstrated the strongest antioxidant activities of ethyl acetate when isolated by silica gel chromatography. This amounts to 84.91.2% of its 0.5 mg ml-1 concentration. The thiobarbituric acid reactive substances (TBARS) measurements from 3 isolations of an HPLC separation of ethyl acetate showed that the antioxidant activity of peak 2 was the most dominant at 84.08% in a 0.5 mg ml-1 concentration. Peak 2 was verified as a type of chromene through EI-Mass and NMR analysis. Its metal sealing characteristic was low while its characteristic of TBARS and DPPH erasure indicated similar or higher levels of metal sealing characteristic. The NMR spectroscopic data was used to elucidate the structure of this new compound, which showed strong antioxidant activity in the assay.

Key words: Antioxidant activity, Chromene, Brown alga, Sargassum siliquastrum

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