![]() |
Journal of Environmental BiologypISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP |
Google Search the Journal web-site: |
Abstract - Issue Mar 2009, 29 (2) BackEffect
of malathion on reproductive system of male rats Nisha Choudhary*, Rekha Goyal and S.C.
Joshi Reproductive
Toxicology Unit, Department of Zoology, (Received:
October 29, 2005 ; Revised received: April 05, 2006 ; Re-revised received: June
25, 06 ; Accepted: August 12, 2006) Abstract: The pesticides are one of the most potentially
harmful chemicals liberated in the environment in an unplanned manner. Malathion is widely used as a potent pesticide in many countries
and has been shown to produce some adverse health effects. A study was
conducted to asses the effects of malathion on the
male reproductive system of wistar rats. The
pesticide was administered to rats orally at dose levels of 50, 150 and 250 mg/kg/body
wt./day for 60 days. In comparison to the control rats, there was a significant
reduction in the weight of testes, epididymis,
seminal vesicle and ventral prostate. Testicular and epididymal
sperm density were decreased in the animals treated with malathion.
Pre and post fertility test showed 80% negative results after treatment.
Biochemical profile of the testis revealed a significant decline in the
contents of sialic acid and glycogen. Whereas a
significant increase in the protein content of testis and testicular
cholesterol was observed. The activity of testicular enzyme acid phosphatase increased significantly, while decreased
alkaline phosphatase activity was found. Malathion also suppressed the level of testosterone
significantly. Results of the present study clearly suggest that malathion induce toxic effects on the male reproductive
system of rats. Key words : Malathion,
Testis, Spermdynamics, Testosterone PDF
of full length paper is available with author (nisha_choudhary@yahoo.com) Copyright © 2008 Triveni Enterprises. All rights reserved. No part of the
Journal can be reproduced in any form without prior
permission. Responsibility regarding the authenticity of the data, and the
acceptability of the conclusions enforced or derived, rest with the author. |