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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Mar 2009, 29 (2)                                     Back


Ovarian development in Labeo dyocheilus (McClelland) during active

Effect of malathion on reproductive system of male rats

Nisha Choudhary*, Rekha Goyal  and S.C. Joshi

Reproductive Toxicology Unit, Department of Zoology, University of Rajasthan, Jaipur-302 004, India

(Received: October 29, 2005 ; Revised received: April 05, 2006 ; Re-revised received: June 25, 06 ; Accepted: August 12, 2006)

Abstract: The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Malathion is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. A study was conducted to asses the effects of malathion on the male reproductive system of wistar rats. The pesticide was administered to rats orally at dose levels of 50, 150 and 250 mg/kg/body wt./day for 60 days. In comparison to the control rats, there was a significant reduction in the weight of testes, epididymis, seminal vesicle and ventral prostate. Testicular and epididymal sperm density were decreased in the animals treated with malathion. Pre and post fertility test showed 80% negative results after treatment. Biochemical profile of the testis revealed a significant decline in the contents of sialic acid and glycogen. Whereas a significant increase in the protein content of testis and testicular cholesterol was observed. The activity of testicular enzyme acid phosphatase increased significantly, while decreased alkaline phosphatase activity was found. Malathion also suppressed the level of testosterone significantly. Results of the present study clearly suggest that malathion induce toxic effects on the male reproductive system of rats. 

Key words : Malathion, Testis, Spermdynamics, Testosterone

PDF of full length paper is available with author (nisha_choudhary@yahoo.com)

 

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