JEB logo

Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

About Journal
    Editor in Chief
    Editorial Board
    Reviewer Panel
    Publication Policies
    Guidelines for Editors
    Guidelines for Reviewers
    Abstracting and Indexing
    Subscription and Payments
    Contact Journal
Read Journal
    Current Issue
    Journal Archives
For Authors
    Guidelines for Authors
    Terms and Conditions
    Fees and Payments
    Track Paper Status
    JEB Awards

Google Search the Journal web-site:

    Abstract - Issue Oct 2007, 28 (4)                                     Back


Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea

leaf extract in streptozotocin induced diabetic rats

P. Pavana1, S.Manoharan*1, G. L. Renju1 and S. Sethupathy2


1Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, India

2Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar-608 002, India

(Received: February 17, 2006 ; Revised received: June 17, 2006 ; Accepted: July 01, 2006)

Abstract: Diabetes mellitus is a worldwide leading metabolic syndrome, associated with profound alterations in carbohydrate, lipids, lipoproteins and protein metabolisms. Worldwide, traditional practitioners for the treatment of diabetes and its complications use a wide variety of medicinal plants. In the present study, the aqueous extract of Tephrosia purpurea leaves (TpALet) was evaluated for its antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats. Profound alterations in the concentrations of blood glucose, lipids and lipoproteins were observed in diabetic rats. Oral administration ofTpALet to diabetic rats at a dose of 600mg/kg body weight significantly reduced the level of blood glucose and increased the level of plasma insulin as well as normalized the lipids and lipoproteins profile. The present study thus demonstrated that TpALet has prominent antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats.

Key words: Diabetes mellitus, Tephrosia purpurea, Streptozotocin, Lipids

††††††††† PDF file of full length paper is available with author


Copyright © 2007 Triveni Enterprises. All rights reserved. No part of the Journal can be reproduced in any form without prior permission.¬†Responsibility regarding the authenticity of the data, and the acceptability of the conclusions enforced or derived, rest completely with the author(s).