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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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        Abstract - Issue Apr Supplement 2007, 28 (2)                                                                                                             Back


Responses of serum calcium and inorganic phosphate levels as well as parathyroid gland and calcitonin producing C cells of Rattus norvegicus to

Mipcin administration

Shaheda P. Rangoonwala1, S.A. Suryawanshi2 and A.K. Pandey*3

1Department of Zoology, Institute of Science, 15 Madam Cama Raoad, Mumbai-400 032, India

2Swami Ramanand Teerth Marathwada University, Nanded-431 606, India

3Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India

(Received: March 24, 2005 ; Revised received: October 25, 2005 ; Accepted: November 11, 2005)

Abstract: Serum calcium (Ca) level of Rattus norvegicus ranged between 13.08+0.41-13.25+ 0.39 mg/100 ml whereas serum inorganic phosphate (Pi) concentration varied between 4.21+ 0.28 - 4.33 + 0.26 mg/100 ml. Sublethal (0.50 LD50 and 0.75 LD50) administration of Mipcin induced a progressive dose-dependent decline in serum Ca level in the rat which was statistically significant at 7 and 14 days. Serum inorganic phosphate level of the treated rats did not exhibit significant fluctuation during the entire course of investigation. Parathyroid chief cells of the experimental rats exhibited degranulation, vacuolation, loss of secretory (hormone) granules and lipid droplets, decreased chromatin in nuclei and damages in the endoplasmic reticulum as well as cristae of mitochondria at 14 days of the treatment. Not much of changes could be seen in the oxyphil cells of parathyroid as well as thyroid C cells of the Mipcin-treated rats.

Key words : Mipcin, Serum calcium, Serum inorganic phosphate, Parathyroid gland, Oxyphil cells, C cells, Rattus norvegicus


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