Journal of Environmental Biology

Responses of serum calcium and inorganic phosphate levels as well as parathyroid gland and calcitonin producing C cells  of Rattus norvegicus to

Mipcin  administration

Shaheda P. Rangoonwala¹, S.A. Suryawanshi² and A.K. Pandey*³

¹Department of Zoology, Institute of Science, 15 Madam Cama Raoad,  Mumbai-400 032, India

²Swami Ramanand Teerth Marathwada University, Nanded-431 606, India

³Central Institute of Freshwater Aquaculture, Kausalyaganga,  Bhubaneswar-751 002, India

(Received: March 24, 2005 ; Revised received: October 25, 2005 ; Accepted: November 11, 2005)

Abstract: Serum calcium (Ca) level of Rattus norvegicus ranged between 13.08+0.41-13.25+ 0.39 mg/100 ml whereas serum inorganic phosphate (Pi) concentration varied between 4.21+ 0.28 - 4.33 + 0.26 mg/100 ml. Sublethal (0.50 LD₅₀ and 0.75 LD₅₀) administration of Mipcin induced a progressive dose-dependent decline in serum  Ca level in the rat which was statistically significant at 7 and 14 days. Serum inorganic phosphate level of the treated rats did not exhibit significant fluctuation during the entire course of investigation. Parathyroid chief cells of the experimental rats exhibited degranulation, vacuolation, loss of secretory (hormone) granules and lipid droplets, decreased chromatin in nuclei and  damages  in the endoplasmic reticulum as well as  cristae of mitochondria at 14 days of the treatment. Not much of changes could  be seen in the oxyphil cells of parathyroid as well as thyroid C cells of the Mipcin-treated rats.

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