Journal of Environmental Biology

Modulating effect of Phyllanthus fruit extract against lead genotoxicity in germ cells of mice

 

D. Madhavi*¹, K. Rudrama Devi¹, K. Kesava Rao¹ and P. P. Reddy²

¹Department of Zoology, College of Science, Osmania University, Hyderabad - 500 007, India

²Institute of Genetics, Hyderabad-500 007, India

(Received: May 20, 2005 ; Revised received: November 29, 2005 ; Accepted: December 17, 2005)

Abstract: The objective of the present study was to evaluate the protective effect of Phyllanthus emblica against clastogenicity induced by lead nitrate on the incidence of sperm head abnormalities in the germ cells of mice. At higher concentration of lead, a significant increase in the percentage of sperm head abnormalities was noted but when animals primed with Phyllanthus fruit extract (PFE), a reduction in the frequency of sperm head abnormalities was observed. It can be suggested from the above study that Phyllanthus emblica plays a key role in inhibition of heavy metal mutagenesis in mammals.

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